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The Ypk1 protein kinase signaling pathway is rewired and not essential for viability in Candida albicans

Authors: Bernardo Ramírez-Zavala, et al. Abstract Protein kinases are central components of almost all signaling pathways that control cellular activities. In the model organism Saccharomyces cerevisiae, the paralogous protein kinases Ypk1 and Ypk2, which control membrane lipid homeostasis, are essential for viability, and previous studies strongly indicated that this is also the case for their…

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Candida albicans selection for human commensalism results in substantial within-host diversity without decreasing fitness for invasive disease

Authors: Faith M. Anderson , et al. Citation: Anderson FM, Visser ND, Amses KR, Hodgins-Davis A, Weber AM, Metzner KM, et al. (2023) Candida albicans selection for human commensalism results in substantial within-host diversity without decreasing fitness for invasive disease. PLoS Biol 21(5): e3001822. https://doi.org/10.1371/journal.pbio.3001822 Academic Editor: Aaron P. Mitchell, University of Georgia, UNITED STATES…

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Integrated post-genomic cell wall analysis reveals floating biofilm formation associated with high expression of flocculins in the pathogen Pichia kudriavzevii

Authors: María Alvarado, et al. Abstract The pathogenic yeast Pichia kudriavzevii, previously known as Candida krusei, is more distantly related to Candida albicans than clinically relevant CTG-clade Candida species. Its cell wall, a dynamic organelle that is the first point of interaction between pathogen and host, is relatively understudied, and its wall proteome remains unidentified…

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