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Targeting FoxO proteins induces lytic reactivation of KSHV for treating herpesviral primary effusion lymphoma

Authors: Jungang Lan , et al. Abstract Kaposi’s sarcoma-associated herpesvirus (KSHV) is an oncogenic virus consisting of both latent and lytic life cycles. Primary effusion lymphoma (PEL) is an aggressive B-cell lineage lymphoma, dominantly latently infected by KSHV. The latent infection of KSHV is persistent and poses an obstacle to killing tumor cells. Like the…

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The shape of cancer relapse: Topological data analysis predicts recurrence in paediatric acute lymphoblastic leukaemia

Authors: Salvador Chulián , et al. Abstract Although children and adolescents with acute lymphoblastic leukaemia (ALL) have high survival rates, approximately 15-20% of patients relapse. Risk of relapse is routinely estimated at diagnosis by biological factors, including flow cytometry data. This high-dimensional data is typically manually assessed by projecting it onto a subset of biomarkers….

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Fumagillin regulates stemness and malignancies in cancer stem-like cells derived from liver cancer via targeting to MetAP-2

Authors: Ke Zhang , et al. Abstract Background Cancer relapse is associated with the presence of cancer stem-like cells (CSCs), which lead to multidirectional differentiation and unrestricted proliferative replication. Fumagillin, a myocotoxin produced by the saprophytic filamentous fungus Aspergillus fumigatus, has been reported to affect malignant characteristics in hepatocellular cancer cells. However, its exact role…

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Patient groups in Rheumatoid arthritis identified by deep learning respond differently to biologic or targeted synthetic DMARDs

Authors: Maria Kalweit, et al. Abstract Cycling of biologic or targeted synthetic disease modifying antirheumatic drugs (b/tsDMARDs) in rheumatoid arthritis (RA) patients due to non-response is a problem preventing and delaying disease control. We aimed to assess and validate treatment response of b/tsDMARDs among clusters of RA patients identified by deep learning. We clustered RA…

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A trial-based cost-utility analysis of sugemalimab vs. placebo as consolidation therapy for unresectable stage III NSCLC in China

Authors: Wei Li , et al. Abstract Objective The effectiveness of sugemalimab vs. placebo in post-chemoradiotherapy patients with locally advanced, unresectable stage III NSCLC has been demonstrated and approved by China National Medical Products Administration. The purpose of this study was to assess the cost-effectiveness of sugemalimab vs. placebo for consolidation treatment of stage III…

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Cytotoxic properties of unfractionated and fractionated bromelain alone or in combination with chemotherapeutic agents in colorectal cancer cells

Authors: Kuei-Yen Tsai, et al. Abstract Background Colorectal cancer (CRC) is one of the most lethal cancers worldwide. Long-term survival is not achieved in metastatic CRC despite the current multidisciplinary therapies. Bromelain, a compound extracted from the pineapple plant, has multiple functions and anticancer properties. Previously, bromelain has been chromatographically separated into four fractions. Fraction…

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The impact of sarcopenia on clinical outcomes in men with metastatic castrate-resistant prostate cancer

Authors: Efthymios Papadopoulos, et al. Abstract Introduction Sarcopenia is common in men with metastatic castrate-resistant prostate cancer (mCRPC) and has been largely assessed opportunistically through computed-tomography (CT) scans, excluding measures of muscle function. Therefore, the impact of a comprehensive assessment of sarcopenia on clinical outcomes in men with mCRPC is poorly understood. The objectives of…

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Extraction, phytochemical characterization and anti-cancer mechanism of Haritaki churna: An ayurvedic formulation

Authors: Md Rafi Uz Zama Khan, et al. 2.1 Chemicals Haritaki churna was purchased from a local Baidyanath store in Guwahati, Assam, India. Dulbecco’s modified eagle’s medium, 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) from Sigma Aldrich (St. Louis, MO, USA) and Percoll were purchased from Sigma (St. Louis, MO, USA). DMSO (cell-culture grade), Foetal Bovine Serum…

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Understanding the medication experience of patients with advanced non-small cell lung cancer taking epidermal growth factor receptor-tyrosine kinase inhibitors: A phenomenological study

Authors: Meng-Jung Wen, et al. Abstract Background and objective Patients with cancer taking oral antineoplastic medications may encounter problems including suboptimal adherence as well as physical and psychological disease burden. Despite increase in the use of oncology pharmacy services, there are wide variations between healthcare professionals and patient perceptions of patients’ medication experiences. The objective…

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Identifying prognostic subgroups of luminal-A breast cancer using deep autoencoders and gene expressions

Authors: Seunghyun Wang, et al. Abstract Luminal-A breast cancer is the most frequently occurring subtype which is characterized by high expression levels of hormone receptors. However, some luminal-A breast cancer patients suffer from intrinsic and/or acquired resistance to endocrine therapies which are considered as first-line treatments for luminal-A breast cancer. This heterogeneity within luminal-A breast…

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