Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity

Authors: Meigen Yu, et al. Abstract Heterozygous variants in the glucocerebrosidase (GBA) gene are common and potent risk factors for Parkinson’s disease (PD). GBA also causes the autosomal recessive lysosomal storage disorder (LSD), Gaucher disease, and emerging evidence from human genetics implicates many other LSD genes in PD susceptibility. We have systemically tested 86 conserved…

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Data-driven segmentation of cortical calcium dynamics

Authors: Sydney C. Weiser , et al. Citation: Weiser SC, Mullen BR, Ascencio D, Ackman JB (2023) Data-driven segmentation of cortical calcium dynamics. PLoS Comput Biol 19(5): e1011085. Editor: Lyle J. Graham, UniversitĂ© Paris Descartes, Centre National de la Recherche Scientifique, FRANCE Received: September 14, 2022; Accepted: April 9, 2023; Published: May 1, 2023…

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