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The σB alternative sigma factor circuit modulates noise to generate different types of pulsing dynamics

Authors: Torkel E. Loman, et al. Citation: Loman TE, Locke JCW (2023) The σB alternative sigma factor circuit modulates noise to generate different types of pulsing dynamics. PLoS Comput Biol 19(8): e1011265. https://doi.org/10.1371/journal.pcbi.1011265 Editor: Tobias Bollenbach, Universitat zu Koln, GERMANY Received: October 10, 2022; Accepted: June 12, 2023; Published: August 4, 2023 Copyright: © 2023…

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Viral vector delivered immunogen focuses HIV-1 antibody specificity and increases durability of the circulating antibody recall response

Authors: LaTonya D. Williams , et al. Abstract The modestly efficacious HIV-1 vaccine regimen (RV144) conferred 31% vaccine efficacy at 3 years following the four-shot immunization series, coupled with rapid waning of putative immune correlates of decreased infection risk. New strategies to increase magnitude and durability of protective immunity are critically needed. The RV305 HIV-1…

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Binding pocket dynamics along the recovery stroke of human β-cardiac myosin

Authors: Fariha Akter, et al. Abstract The druggability of small-molecule binding sites can be significantly affected by protein motions and conformational changes. Ligand binding, protein dynamics and protein function have been shown to be closely interconnected in myosins. The breakthrough discovery of omecamtiv mecarbil (OM) has led to an increased interest in small molecules that…

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A glycan receptor kinase facilitates intracellular accommodation of arbuscular mycorrhiza and symbiotic rhizobia in the legume Lotus japonicus

Authors: Simon Kelly , et al. Abstract Receptors that distinguish the multitude of microbes surrounding plants in the environment enable dynamic responses to the biotic and abiotic conditions encountered. In this study, we identify and characterise a glycan receptor kinase, EPR3a, closely related to the exopolysaccharide receptor EPR3. Epr3a is up-regulated in roots colonised by…

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