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Lmo4 synergizes with Fezf2 to promote direct in vivo reprogramming of upper layer cortical neurons and cortical glia towards deep-layer neuron identities

Authors: Torsten Felske , et al. Citation: Felske T, Tocco C, Péron S, Harb K, Alfano C, Galante C, et al. (2023) Lmo4 synergizes with Fezf2 to promote direct in vivo reprogramming of upper layer cortical neurons and cortical glia towards deep-layer neuron identities. PLoS Biol 21(8): e3002237. https://doi.org/10.1371/journal.pbio.3002237 Academic Editor: Bassem A. Hassan, ICM,…

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Design of an adaptable intrafascicular electrode (AIR) for selective nerve stimulation by model-based optimization

Authors: Federico Ciotti, et al. Abstract Peripheral nerve stimulation is being investigated as a therapeutic tool in several clinical scenarios. However, the adopted devices have restricted ability to obtain desired outcomes with tolerable off-target effects. Recent promising solutions are not yet employed in clinical practice due to complex required surgeries, lack of long-term stability, and…

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Monosynaptic trans-collicular pathways link mouse whisker circuits to integrate somatosensory and motor cortical signals

Authors: Jesús Martín-Cortecero , et al. Abstract The superior colliculus (SC), a conserved midbrain node with extensive long-range connectivity throughout the brain, is a key structure for innate behaviors. Descending cortical pathways are increasingly recognized as central control points for SC-mediated behaviors, but how cortico-collicular pathways coordinate SC activity at the cellular level is poorly…

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