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Development of AlissAID system targeting GFP or mCherry fusion protein

Authors: Yoshitaka Ogawa , et al. Abstract Conditional control of target proteins using the auxin-inducible degron (AID) system provides a powerful tool for investigating protein function in eukaryotes. Here, we established an Affinity-linker based super-sensitive auxin-inducible degron (AlissAID) system in budding yeast by using a single domain antibody (a nanobody). In this system, target proteins…

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Tight basis cycle representatives for persistent homology of large biological data sets

Authors: Manu Aggarwal , et al. Abstract Persistent homology (PH) is a popular tool for topological data analysis that has found applications across diverse areas of research. It provides a rigorous method to compute robust topological features in discrete experimental observations that often contain various sources of uncertainties. Although powerful in theory, PH suffers from…

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