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Targeting FoxO proteins induces lytic reactivation of KSHV for treating herpesviral primary effusion lymphoma

Authors: Jungang Lan , et al. Abstract Kaposi’s sarcoma-associated herpesvirus (KSHV) is an oncogenic virus consisting of both latent and lytic life cycles. Primary effusion lymphoma (PEL) is an aggressive B-cell lineage lymphoma, dominantly latently infected by KSHV. The latent infection of KSHV is persistent and poses an obstacle to killing tumor cells. Like the…

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DHX38 restricts chemoresistance by regulating the alternative pre-mRNA splicing of RELL2 in pancreatic ductal adenocarcinoma

Authors: Zeru Li , et al. Abstract Intron retention plays an important role in cancer progression and chemotherapy resistance and seems to be essential for the maintenance of genome stability in cancer. Here, our goal was to analyze the role of receptor expressed in lymphoid tissue (Relt)-like 2 (RELL2) intron 4 retention in promoting pancreatic…

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Damage sensing mediated by serine proteases Hayan and Persephone for Toll pathway activation in apoptosis-deficient flies

Authors: Shotaro Nakano, et al. Citation: Nakano S, Kashio S, Nishimura K, Takeishi A, Kosakamoto H, Obata F, et al. (2023) Damage sensing mediated by serine proteases Hayan and Persephone for Toll pathway activation in apoptosis-deficient flies. PLoS Genet 19(6): e1010761. https://doi.org/10.1371/journal.pgen.1010761 Editor: Norbert Perrimon, Harvard Medical School, Howard Hughes Medical Institute, UNITED STATES Received:…

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Pterostilbene mediates glial and immune responses to alleviate chronic intermittent hypoxia-induced oxidative stress in nerve cells

Authors: Peijun Liu, et al. Abstract Chronic intermittent hypoxia (CIH) induces oxidative stress in the brain, causing sleep disorders. Herein, we investigated the role of pterostilbene (Pte) in CIH-mediated oxidative stress in the brain tissue. A CIH mouse model was constructed by alternately reducing and increasing oxygen concentration in a sealed box containing the mouse;…

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Cytotoxic properties of unfractionated and fractionated bromelain alone or in combination with chemotherapeutic agents in colorectal cancer cells

Authors: Kuei-Yen Tsai, et al. Abstract Background Colorectal cancer (CRC) is one of the most lethal cancers worldwide. Long-term survival is not achieved in metastatic CRC despite the current multidisciplinary therapies. Bromelain, a compound extracted from the pineapple plant, has multiple functions and anticancer properties. Previously, bromelain has been chromatographically separated into four fractions. Fraction…

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Extraction, phytochemical characterization and anti-cancer mechanism of Haritaki churna: An ayurvedic formulation

Authors: Md Rafi Uz Zama Khan, et al. 2.1 Chemicals Haritaki churna was purchased from a local Baidyanath store in Guwahati, Assam, India. Dulbecco’s modified eagle’s medium, 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) from Sigma Aldrich (St. Louis, MO, USA) and Percoll were purchased from Sigma (St. Louis, MO, USA). DMSO (cell-culture grade), Foetal Bovine Serum…

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Mutual repression between JNK/AP-1 and JAK/STAT stratifies senescent and proliferative cell behaviors during tissue regeneration

Authors: Janhvi Jaiswal, et al. Citation: Jaiswal J, Egert J, Engesser R, Peyrotón AA, Nogay L, Weichselberger V, et al. (2023) Mutual repression between JNK/AP-1 and JAK/STAT stratifies senescent and proliferative cell behaviors during tissue regeneration. PLoS Biol 21(5): e3001665. https://doi.org/10.1371/journal.pbio.3001665 Academic Editor: Philipp Niethammer, Harvard Medical School, UNITED STATES Received: April 26, 2022; Accepted:…

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Bcl-xL is required to protect endothelial cells latently infected with KSHV from virus induced intrinsic apoptosis

Authors: Lyndsey N. Moore, et al. Abstract Kaposi’s Sarcoma herpesvirus (KSHV) is the etiologic agent of Kaposi’s Sarcoma (KS), a highly vascularized tumor common in AIDS patients and many countries in Africa. KSHV is predominantly in the latent state in the main KS tumor cell, the spindle cell, a cell expressing endothelial cell markers. To…

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