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The bacterial genetic determinants of Escherichia coli capacity to cause bloodstream infections in humans

Authors: Judit Burgaya , et al. Abstract Escherichia coli is both a highly prevalent commensal and a major opportunistic pathogen causing bloodstream infections (BSI). A systematic analysis characterizing the genomic determinants of extra-intestinal pathogenic vs. commensal isolates in human populations, which could inform mechanisms of pathogenesis, diagnostic, prevention and treatment is still lacking. We used…

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Antimicrobial resistance: Strengthening surveillance for public health action

Authors: Silvia Bertagnolio , et al. Citation: Bertagnolio S, Suthar AB, Tosas O, Van Weezenbeek K (2023) Antimicrobial resistance: Strengthening surveillance for public health action. PLoS Med 20(7): e1004265. https://doi.org/10.1371/journal.pmed.1004265 Published: July 12, 2023 Copyright: © 2023 World Health Organization. Licensee Public Library of Science. This is an open access article distributed under the Creative…

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Understanding the impact of antimicrobial resistance on outcomes of bloodstream infections in low- and middle-income countries

Authors: Marlieke E. A. de Kraker et al. Citation: de Kraker MEA (2023) Understanding the impact of antimicrobial resistance on outcomes of bloodstream infections in low- and middle-income countries. PLoS Med 20(7): e1004262. https://doi.org/10.1371/journal.pmed.1004262 Published: July 12, 2023 Copyright: © 2023 Marlieke E. A. de Kraker. This is an open access article distributed under the…

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Implications of reducing antibiotic treatment duration for antimicrobial resistance in hospital settings: A modelling study and meta-analysis

Authors: Yin Mo , et al. Abstract Background Reducing antibiotic treatment duration is a key component of hospital antibiotic stewardship interventions. However, its effectiveness in reducing antimicrobial resistance is uncertain and a clear theoretical rationale for the approach is lacking. In this study, we sought to gain a mechanistic understanding of the relation between antibiotic…

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Advances in understanding infections caused by the basal fungus Mucor

Authors: José T. Cánovas-Márquez , et al. Citation: Cánovas-Márquez JT, Lax C, Tahiri G, Navarro E, Nicolás FE, Garre V (2023) Advances in understanding infections caused by the basal fungus Mucor. PLoS Pathog 19(6): e1011394. https://doi.org/10.1371/journal.ppat.1011394 Editor: Anuradha Chowdhary, Vallabhbhai Patel Chest Institute, INDIA Published: June 1, 2023 Copyright: © 2023 Cánovas-Márquez et al. This…

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Global, regional, and national estimates of the impact of a maternal Klebsiella pneumoniae vaccine: A Bayesian modeling analysis

Authors: Chirag K. Kumar, et al. Abstract Background Despite significant global progress in reducing neonatal mortality, bacterial sepsis remains a major cause of neonatal deaths. Klebsiella pneumoniae (K. pneumoniae) is the leading pathogen globally underlying cases of neonatal sepsis and is frequently resistant to antibiotic treatment regimens recommended by the World Health Organization (WHO), including…

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Evolution, persistence, and host adaption of a gonococcal AMR plasmid that emerged in the pre-antibiotic era

Authors: Wearn-Xin Yee, et al. Citation: Yee W-X, Yasir M, Turner AK, Baker DJ, Cehovin A, Tang CM (2023) Evolution, persistence, and host adaption of a gonococcal AMR plasmid that emerged in the pre-antibiotic era. PLoS Genet 19(5): e1010743. https://doi.org/10.1371/journal.pgen.1010743 Editor: Xavier Didelot, University of Warwick, UNITED KINGDOM Received: January 20, 2023; Accepted: April 14,…

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