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Impact of stabilizing mutations on the antigenic profile and glycosylation of membrane-expressed HIV-1 envelope glycoprotein

Authors: Tommy Tong, et al. Introduction HIV-1 envelope glycoprotein (Env) gp120/gp41 trimers are the natural target of broadly neutralizing antibodies (bNAbs). These trimers use sophisticated strategies to evade bNAbs, including high sequence variation of exposed surfaces, a dense glycan shield, low viral spike density and conformationally dynamic epitopes [1–4]. Env trimers can assume various conformations,…

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Enhanced stability of the SARS CoV-2 spike glycoprotein following modification of an alanine cavity in the protein core

Authors: Pantelis Poumbourios , et al. Abstract The spike (S) glycoprotein of SARS CoV-2 is the target of neutralizing antibodies (NAbs) that are crucial for vaccine effectiveness. The S1 subunit binds ACE2 while the S2 subunit mediates virus-cell membrane fusion. S2 is a class I fusion glycoprotein subunit and contains a central coiled coil that…

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Identification of CDRH3 loops in the B cell receptor repertoire that can be engaged by candidate immunogens

Authors: Olivia Swanson , et al. Abstract A major goal for the development of vaccines against rapidly mutating viruses, such as influenza or HIV, is to elicit antibodies with broad neutralization capacity. However, B cell precursors capable of maturing into broadly neutralizing antibodies (bnAbs) can be rare in the immune repertoire. Due to the stochastic…

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