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Innate lymphoid cells—Underexplored guardians of immunity

Authors: Irina Tsymala, et al. Citation: Tsymala I, Kuchler K (2023) Innate lymphoid cells—Underexplored guardians of immunity. PLoS Pathog 19(10): e1011678. https://doi.org/10.1371/journal.ppat.1011678 Editor: Mary Ann Jabra-Rizk, University of Maryland, Baltimore, UNITED STATES Published: October 19, 2023 Copyright: © 2023 Tsymala, Kuchler. This is an open access article distributed under the terms of the Creative Commons…

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Immunocompetent hamsters as a model for orthobunyavirus-induced neuroinvasion and neuropathology

Authors: Allison Groseth, et al. Abstract Background Bunyavirus infections, including those caused by Bunyamwera serogroup orthobunyaviruses, represent a significant and yet likely still vastly underappreciated cause of mild to moderate human febrile infections. In severe cases, these infections can also cause neurological disease, particularly meningitis and encephalitis, and infection can even be fatal. However, with…

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Upregulation of LAG3 modulates the immune imbalance of CD4+ T-cell subsets and exacerbates disease progression in patients with alveolar echinococcosis and a mouse model

Authors: Dewei Li , et al. Abstract Infection with the cestode Echinococcus multilocularis (E. multilocularis) causes alveolar echinococcosis (AE), a tumor-like disease predominantly affecting the liver but able to spread to any organ. T cells develop functional defects during chronic E. multilocularis infection, mostly due to upregulation of inhibitory receptors such as T-cell immunoreceptor with…

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