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lhCLIP reveals the in vivo RNA–RNA interactions recognized by hnRNPK

Authors: Yuanlang Hu, et al. Abstract RNA-RNA interactions play a crucial role in regulating gene expression and various biological processes, but identifying these interactions on a transcriptomic scale remains a challenge. To address this, we have developed a new biochemical technique called pCp-biotin labelled RNA hybrid and ultraviolet crosslinking and immunoprecipitation (lhCLIP) that enables the…

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CAG repeat expansion in the Huntington’s disease gene shapes linear and circular RNAs biogenesis

Authors: Dilara Ayyildiz , et al. Abstract Alternative splicing (AS) appears to be altered in Huntington’s disease (HD), but its significance for early, pre-symptomatic disease stages has not been inspected. Here, taking advantage of Htt CAG knock-in mouse in vitro and in vivo models, we demonstrate a correlation between Htt CAG repeat length and increased…

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