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The Ypk1 protein kinase signaling pathway is rewired and not essential for viability in Candida albicans

Authors: Bernardo Ramírez-Zavala, et al. Abstract Protein kinases are central components of almost all signaling pathways that control cellular activities. In the model organism Saccharomyces cerevisiae, the paralogous protein kinases Ypk1 and Ypk2, which control membrane lipid homeostasis, are essential for viability, and previous studies strongly indicated that this is also the case for their…

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Segregational drift hinders the evolution of antibiotic resistance on polyploid replicons

Authors: Ana Garoña , et al. Abstract The emergence of antibiotic resistance under treatment depends on the availability of resistance alleles and their establishment in the population. Novel resistance alleles are encoded either in chromosomal or extrachromosomal genetic elements; both types may be present in multiple copies within the cell. However, the effect of polyploidy…

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Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity

Authors: Meigen Yu, et al. Abstract Heterozygous variants in the glucocerebrosidase (GBA) gene are common and potent risk factors for Parkinson’s disease (PD). GBA also causes the autosomal recessive lysosomal storage disorder (LSD), Gaucher disease, and emerging evidence from human genetics implicates many other LSD genes in PD susceptibility. We have systemically tested 86 conserved…

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