Dermatopathology, Vol. 10, Pages 142-146: Spiny Keratoderma in Association with Melanoma
Dermatopathology doi: 10.3390/dermatopathology10020021
Thaddeus W. Mully
Maria L. Wei
Spiny keratoderma (SK) was first described by Brown in 1871 and is characterized by numerous 1&ndash;2 mm spines of keratin on the palms and soles, usually sparing the dorsal surfaces, or disseminated over the trunk. Histologically, the &ldquo;spine&rdquo; represents a column of hyperkeratosis. Several different forms are known, including familial, sporadic, post-inflammatory and paraneoplastic. Although an association of SK with melanoma has been reported, the significance of such co-occurrence remains unclear due to the limited number of cases. To increase the body of knowledge and shed further light on this rare condition, we present a case of SK in a patient with a recent history of melanoma in situ.
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