Biomedicines, Vol. 11, Pages 1499: Valproate-Induced Metabolic Syndrome


Biomedicines, Vol. 11, Pages 1499: Valproate-Induced Metabolic Syndrome

Biomedicines doi: 10.3390/biomedicines11051499

Natalia A. Shnayder
Violetta V. Grechkina
Vera V. Trefilova
Ilya S. Efremov
Evgenia A. Dontceva
Ekaterina A. Narodova
Marina M. Petrova
Irina A. Soloveva
Liia E. Tepnadze
Polina A. Reznichenko
Mustafa Al-Zamil
Gulnara I. Altynbekova
Anna I. Strelnik
Regina F. Nasyrova

Valproic acid (VPA) and its salts (sodium calcium magnesium and orotic) are psychotropic drugs that are widely used in neurology and psychiatry. The long-term use of VPA increases the risk of developing adverse drug reactions (ADRs), among which metabolic syndrome (MetS) plays a special role. MetS belongs to a cluster of metabolic conditions such as abdominal obesity, high blood pressure, high blood glucose, high serum triglycerides, and low serum high-density lipoprotein. Valproate-induced MetS (VPA-MetS) is a common ADR that needs an updated multidisciplinary approach to its prevention and diagnosis. In this review, we consider the results of studies of blood (serum and plasma) and the urinary biomarkers of VPA-MetS. These metabolic biomarkers may provide the key to the development of a new multidisciplinary personalized strategy for the prevention and diagnosis of VPA-MetS in patients with neurological diseases, psychiatric disorders, and addiction diseases.

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